Grape compounds able to block a key enzyme in the Covid-19 virus

Tuesday January 12 2021 by Vitisphere

 In April, a Chinese team synthesised two compounds that inhibit the Mpro enzyme, with good in vivo results in dogs and mice. Their work was published in Science Magazine. In April, a Chinese team synthesised two compounds that inhibit the Mpro enzyme, with good in vivo results in dogs and mice. Their work was published in Science Magazine. - Photo credit : MSA

The antiviral properties of certain fruits such as persimmons have been well documented. Researchers at North Carolina State University recently discovered that raw extracts of green tea, cocoa and two varieties of muscadine grapes (Vitis rotundifolia) harvested in the United States as table or wine grapes are also capable of inhibiting the function of SARS-Cov-2, which causes Covid-19.

These foods have abundant flavan-3-ols and proanthocyanidins and disrupt the way the virus replicates and attaches itself to human cells”, said De-Yu Xie, the study's lead author. The researchers conducted in vitro laboratory experiments which showed that the polyphenols inhibited the virus by binding with its Mpro protease and they insist that polyphenols could play a part in a pandemic therapy.

According to American researchers, flavanols and proanthocyanidins in grapes and wine prevent the SARS-CoV-2 virus from attaching itself to human cells. The polyphenols, which are also present in green tea and cocoa, could thus help in the fight against the pandemic.

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